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The overall solution | C- reactive protein, what does it reflect?

2024-10-14

What is C- Reactive Protein (C-reactive protein,CRP)?

CRP is an acute-phase reactive protein named for its ability to react with pneumococcal C- polysaccharide.

The natural CRP is a pentameric structure (pCRP), consisting of five identical spherical subunits, with a relative molecular mass of about 115KD, surrounded by a pore structure in the middle, and its concave surface containing ligand binding sites.

(Data source Yao Z, et al. Inflamm Res. 2019)

CRP is mainly synthesized in the liverThe gene coding is located on chromosome 1, and the transcription level is regulated by cytokine IL-6, which is also one of the relationships between IL-6 and CRP.

Under normal circumstances, the level of CRP in the blood is very low, less than 1 μg/mL,Trace changes in CRP can indicate changes in human physiological conditions.

When the body is infected or stimulated by inflammation, the liver cells will synthesize a large amount of CRP and release it into the blood. After about 10 h, CRP began to increase significantly, reaching the peak at 36-50 h. The half-life of CRP is 19 h (adult, neonatal 21 h). If the inflammation goes away, CRP will drop to normal levels within a few days.

Clinical significance of CRP

Early warning and monitoring of infection: CRP will increase after the onset of various diseases such as inflammation and tissue damage, and its increase is positively correlated with the degree of infection. CRP in patients after surgery will increase and drop after 7-10 days. If CRP rises again, it may be complicated by infection or thromboembolism.
Determine the efficacy of antibiotics: Effective antibiotic treatment can significantly reduce CRP.
Helps identify the type of respiratory infection: CRP levels are elevated in bacterial infections; CRP levels are not elevated or slightly elevated in viral infections.

Full range of CRP, CRP and hypersensitive CRP

Hypersensitive CRP is not a new CRP, but is named according to the detection methodology with higher sensitivity in the low concentration (1-10mg/L) range. In clinical use, it is mainly used for cardiovascular disease risk assessment and diagnosis of neonatal bacterial infection.

Common CRP is often used as a preferred indicator to identify bacterial and viral infections. The detection range of the method is generally 10-200mg/L.

(Image Source Network)

Full range CRP is the "full range measurement" CRP that contains both ordinary CRP and hypersensitive CRP.

Therefore, the current clinical and laboratory consensus is generally formed:Below 10mg/L, it is mainly used to monitor cardiovascular diseases such as coronary heart disease; while above 10mg/L, it is often used to diagnose bacterial inflammatory diseases.

Full Range CRP Total Solution for Vertical Top Medical