Nanjing Leading Medical Technology Co., Ltd.

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Two cannons fire in unison, breaking new ground through innovation! Leading Medical has secured two additional invention patents!

A grand celebration marking Leading Medical’s successive acquisition of two invention patents: A monoclonal antibody against HbA1c and its applications 、 A carboxylated polystyrene microsphere, its preparation method, and its application in quantitative assay kits. Liding products boast independent intellectual property rights, and the continuous accumulation of patent achievements underscores our robust R&D capabilities and the steady advancement of our technological expertise.

Breaking Through Bottlenecks and Pioneering New Paths

A monoclonal antibody against HbA1c and its applications

Current methods for preparing HbA1c assay reagents are cumbersome, relatively costly, and prone to antibody activity loss, thereby compromising reagent stability; moreover, conventional immunoassay techniques suffer from limitations in both sensitivity and specificity.

To this end, Leading Medical has specifically developed a… HbA1c monoclonal antibody It can be used to prepare latex immunoturbidimetric assay reagents and immunochromatographic assay reagents. By optimizing the formulation of a specific buffer and the antibody-to‑antigen ratio, the accuracy and stability of the assays are enhanced. Significant Enhancement.

A carboxylated polystyrene microsphere, its preparation method, and its application in an MxA quantitative assay kit.

Currently available carboxylated polystyrene microspheres exhibit low binding efficiency with antibodies, resulting in poor antigen detection sensitivity and particularly reduced accuracy when analyzing low-concentration samples.

Polystyrene microspheres with a surface rich in carboxyl groups, prepared using this patented technology, exhibit enhanced carboxyl group density and binding capacity, thereby significantly improving… Antibody immobilization efficiency and detection sensitivity , enabling highly sensitive quantitative antigen detection, shortening assay turnaround time, and enhancing the accuracy of detecting low‑concentration analytes.

Technology is the primary productive force, and innovation is the core engine of enterprise development. As one of the first domestic companies to obtain patent authorization for antibodies used in diabetes‑related biomarker detection, as well as for core materials and preparation technologies of diagnostic reagents for infectious diseases, Liding has translated its patented innovations into practical testing products, thereby supporting early, precise disease diagnosis in the fields of clinical biochemistry and immunochromatography.

Leading Biochemical Immunoassay Reagents – Diabetes Detection Series

Testing indicators	Reagent ratio	Core Explanation	Methodology
Glycated hemoglobin ( HbA1c )	R1:R2=3:1	LD-HbA1c-05	Latex-enhanced immunoturbidimetric assay
Glycated albumin ( GA )	R1:R2:R3=3:1:4	LD-GA-01	Enzymatic method
Adenosine diphosphate ( ADP )	R1:R2=4:1	LD-ADP-01	Latex-enhanced immunoturbidimetric assay
Albumin ( ALB )	R:S=100:1	LD-ALB-01	Enzymatic method
β-Hydroxybutyric acid ( β-Hydroxybutyrate )	R1:R2=3:1	LD-β-HB-01	Enzymatic method
Glycated serum protein ( GSP )	R1:R2=3:1	LD-GSP-01	Nitroblue tetrazolium method
Glucose ( GLU )	R1:R2=4:1	LD-GLU-01	Enzymatic method

Liding Immunochromatographic Reagents – Inflammation Detection Series

PCT/IL-6 Dual-Assay Kit (Fluorescent Immunochromatographic Assay)

SAA Test Kit (Fluorescent Immunochromatographic Assay)

CRP Test Kit (Fluorescent Immunochromatographic Assay)

SAA/CRP Dual-Test Kit (Fluorescent Immunochromatographic Assay) )

Liding’s Core Raw Material—Nano-Microsphere Series

Type	Item number	English abbreviation	Surface modification	Particle size	Solid content	PDI	COOH content (mmol/g)	Application Project
White latex microspheres	LD-Latex-P140	P140	/	(145–165) nm	10%	<0.05	/	HbA1c
	LD102011	⭐ LD-PS2116	/	(145–165) nm	10%	<0.05	/	HbA1c
	LD102030	PL60	COOH	(55-65) nm	5%	<0.05	0.25-0.30	SAA
	LD102031	PL70	COOH	(70–85) nm	5%	<0.05	0.25-0.30	SAA, CRP
	LD102019	PL80	COOH	(75–85) nm	5%	<0.05	0.25-0.30	CRP
	LD102028	PL90	COOH	(83-98) nm	5%	<0.05	0.25-0.30	RBP
	LD102010	PL100	COOH	(96–110) nm	5%	<0.05	0.15-0.20	mAlb
	LD102021	LD-PS0011	COOH	(100-110) nm	5%	<0.05	0.14-0.18	SAA
	LD102029	PL120	COOH	(115-135) m	10%	<0.05	0.12-0.16	CysC, LP(a)
	LD102012	PL150CL	COOH	(148–160) nm	10%	<0.05	0.12-0.16	ASO
	LD102032	PL150CH	COOH	(138–150) nm	10%	<0.05	0.14-0.18	SAA
	LD102023	PL180	COOH	(175-185) nm	10%	<0.05	0.12-0.16	D-Dimer
	LD102024	PL180-M	COOH	(180–190) nm	10%	<0.05	0.14-0.18	D-Dimer
	LD102016	PL200-H	COOH	(200–220) nm	10%	<0.05	0.15-0.20	CRP, D-Dimer
	LD102025	PL220	COOH	(215–235) nm	10%	<0.05	0.12-0.16	CRP, D-Dimer
	LD102015	PL300	COOH	(305-320) nm	10%	<0.05	0.07-0.11	D-Dimer
	LD102026	PS400A	COOH	(390–400) nm	10%	<0.05	0.05-0.10	CRP (slide test)
	LD102027	PS400B	COOH	(380–390) nm	10%	<0.05	0.05-0.10	CKMB

Product Name	Abbreviation	Item number	Surface modification	Particle size	Solid content	PDI	Application Project
Red latex microspheres	PR300	LD202002	COOH	300nm	4%	<0.05	Qualitative immunochromatography
Red latex microspheres	PR400	LD202003	COOH	400nm	4%	<0.05
Purple latex microspheres	PP300	LD202010	COOH	300nm	4%	<0.05
Purple latex microspheres	PP400	LD202011	COOH	400nm	4%	<0.05
Blue latex microspheres	PB300	LD202005	COOH	300nm	4%	<0.05
Blue latex microspheres	PB400	LD202006	COOH	400nm	4%	<0.05
Black latex microspheres	PH300	LD202008	COOH	300nm	4%	<0.05
Black latex microspheres	PH400	LD202009	COOH	400nm	4%	<0.05
Time-resolved fluorescent microspheres	Eu300	LD302017	COOH	300 nm	1%	<0.05	Quantitative immunochromatography
Time-resolved fluorescent microspheres	Eu400	LD302018	COOH	400 nm	1%	<0.05	Quantitative immunochromatography

Liding Core Raw Materials—Antigen/Antibody Series

Natural antigen
Product Name	Item number	Form	Source
High glycated hemoglobin levels	LD-Ag-HbA1c-04	Lyophilized powder	Whole blood
Low glycated hemoglobin levels	LD-Ag-HbA1c-03	Lyophilized powder	Whole blood
C-reactive protein	LD-Ag-CRP-N	Liquid	Serum
D-dimer	LD-Ag-DD	Liquid	Plasma
Fibrin (ogen) degradation products	LD-Ag-FDP	Liquid	Plasma
Lipoprotein(a)	LD-Ag-Lpa	Liquid	Serum
Retinol-binding protein	LD-Ag-RBP	Liquid	Serum
Complement C1q	LD-Ag-C1q	Liquid	Serum
Angiotensin-converting enzyme	LD-En-ACE	Lyophilized powder	Serum
Apolipoprotein ApoA1	LD-Ag-ApoA1	Lyophilized powder	Serum
Apolipoprotein ApoB	LD-Ag-ApoB	Lyophilized powder	Serum

Recombinant antigen
Product Name	Item number	Form
Adiponectin	LD-Ag-ADP	Liquid
Pepsinogen I	LD-Ag-PGⅠ	Liquid
Pepsinogen II	LD-Ag-PGⅡ	Liquid
Heparin-binding protein-02	LD-Ag-HBP	Liquid
Serum amyloid A	LD-Ag-SAA	Liquid
Procalcitonin	LD-Ag-PCT	Liquid
C-reactive protein	LD-Ag-CRP-R	Liquid
Lipoprotein-associated phospholipase A2	LD-Ag-Lp-PLA2	Liquid
Prealbumin	LD-Ag-PA	Liquid
Cystatin C	LD-Ag-CysC	Liquid
SLO protein	LD-Pn-SLO	Liquid

Type	Application Project	Item number
HbA1c monoclonal antibody oligomer	HbA1c	LD-mAb-HbA1c-06
Mouse anti-human monoclonal antibody	HbA1c	LD-mAb-HbA1c
	ADP	LD-mAb-ADP
	PGI	LD-mAb-PGI
	PGII	LD-mAb-PGII
	HBP	LD-mAb-HBP
	SAA	LD-mAb-SAA
	D-Dimer	LD-mAb-DD
	FDP	LD-mAb-FDP
	Lp-PLA2	LD-mAb-Lp-PLA2
	CKMB	LD-mAb-CKMB
	C1q	LD-mAb-C1q
	CRP	LD-mAb-CRP
Rabbit anti-human polyclonal antibody	SAA	LD-rpAb-SAA
	CRP	LD-rpAb-CRP
	PCT	LD-rpAb-PCT
Sheep anti-human polyclonal antibody	CRP	LD-gpAb-CRP
	RBP	LD-gpAb-RBP
	Lpa	LD-gpAb-Lpa
	CysC	LD-gpAb-CysC
Sheep anti-mouse polyclonal antibody	HbA1c	LD-gpAb-HbA1c
Apolipoprotein A1 Antiserum	ApoA1	LD-As-ApoA1
Apolipoprotein B antiserum	ApoB	LD-As-ApoB
Prealbumin antiserum	PA	LD-AS-PA

Leading Medical

Leading Medical as Professional service provider of upstream products for IVD companies , has been committed to providing the in vitro diagnostics industry with High-quality raw materials, premium OEM reagents and also Efficient Product Solutions Currently, our products serve more than 200 enterprises both domestically and internationally, earning the support and recognition of a broad customer base.

Currently, our company CDMO product line Has successfully developed to cover Cardiovascular series, Thyroid function series, Diabetes Series, Infectious Diseases Series , Inflammation Series and a variety of high-quality raw materials and corresponding products; meanwhile, the company has now successfully established Biochemistry Immunity , intermediate product lines such as specific proteins, POCT chromatography, and chemiluminescence , providing customers with a comprehensive solution suite 。