Nanjing Leading Medical Technology Co., Ltd.

Home page

Microchimica Acta: A Major Breakthrough—The Liding Team Achieves a New Milestone, Revolutionizing the Detection of Infectious Biomarkers with a Low-Cost, High-Performance Microsphere Platform

Recently, Dr. Zhang Yujie, General Manager of Leading Medical, served as the first author. , leading Liding Microsphere and Immunochromatographic Assay R&D Team , in internationally renowned journals Microchimica Acta (2026, 193:435) published a groundbreaking research paper titled “Surfactant-free polymer microspheres with molecular confinement-enabled optical encoding for dual-color immunochromatographic assays.”

Liding Team’s Innovative Research and Development Molecular Confinement–Assisted Optical Encoding Technology , we have developed surfactant-free colored polymer microspheres, effectively addressing many of the longstanding challenges in conventional immunochromatographic assays and paving the way for low-cost, high-performance materials and diagnostic platforms to enable simultaneous, rapid screening of novel infectious biomarkers.

In the field of infectious disease prevention and control, rapid differentiation of infection types is a core requirement of point-of-care testing (POCT), as it both guides precision medicine and curtails the overuse of antibiotics, while also helping to contain the spread of antibiotic‑resistant strains.

Currently, mainstream lateral flow immunoassay (LFIA) technologies largely rely on gold nanoparticles as colorimetric reporters. However, these materials suffer from significant drawbacks: a limited tunability of color, particle aggregation that leads to signal instability, a complex preparation process, relatively high production costs, and poor assay reproducibility—factors that severely hinder the development of multiplexed, simultaneous visual detection. To address these challenges, the Leading R&D team has developed a platform based on… Styrene–Methyl Methacrylate Copolymer (PSA) By developing a dual‑functional microsphere system and integrating a hydrothermal swelling–shrinkage molecular confinement process, we have engineered surfactant‑free, color‑coded microspheres with stable optical properties and outstanding bioactivity. Their core advantages are particularly compelling:

✅ Formulated without surfactants, with significantly enhanced bio‑binding performance.

✅ Molecularly confined immobilized dyes exhibit outstanding optical and colloidal stability.

✅ Multi-color coding offers strong versatility and is compatible with multi-channel simultaneous testing scenarios.

Built upon novel color-coded microspheres Bicolor Immunochromatographic Assay Platform , enabling the simultaneous visual detection of two types of novel infection biomarkers, with outstanding overall analytical performance:

✅ Detection is efficient and convenient, with ideal results visible to the naked eye.

✅ Strong anti-interference capability

✅ Excellent repeatability and storage stability

✅ No signal crosstalk

This versatile optical‑encoding platform boasts a wide range of application scenarios; beyond infectious‑disease screening, it can also be extended to inflammation monitoring, food safety, and numerous other POCT fields. Looking ahead, Liding Microspheres and the immunochromatographic R&D team will continue to drive the translation of this technology into practical applications, refining and optimizing it to support the innovative advancement of high‑performance, low‑cost in vitro diagnostic products.

Congratulations to Dr. Zhang Yujie and all members on… 《 Microchimica Acta 》 An important achievement—may Leading Medical continue to pioneer at the forefront of technology, deliver more impactful research findings and high‑quality products, and remain a leader in innovation within the field of precision diagnostics!